Kim sa, ahn sg, kim sg, park jc, lee sh, kim j, yoon jh. Odontogenic tumors and allied lesions edition 1 by peter. Dentinogenic ghost cell tumors dgcts are uncommon neoplasms classified as a solid variant of the calcifying odontogenic cyst and defined as a locally invasive. A transition from basaloid to ghost cells is seen in most areas which may be abrupt or gradual. Odontogenic ghost cell carcinomas ogcc are rare and only a dozen or so have been reported in the literature. Investigation of the betacatenin gene in a case of dentinogenic ghost cell tumor. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor previously called clear cell ameloblastoma considered benign by who of 1992, but due to its high potential for regional spread and distant metastases, it was reclassified as malignant in 2005. Hassanein am, glanz sm, kessler hp, eskin ta, liu c. The burr hole was then filled with spongostan ferrosan as, soeborg, denmark and the scalp sutured. Dentinogenic ghost cell tumor dgct is a very rare benign, but locally. Ghost cell odontogenic carcinoma arising from calcifying. Calcifying odontogenic cyst constitutes 1 to 2% of all odontogenic tumors in which 88. Dentinogenic ghost cell tumor of the peripheral variant. The dentinogenic ghost cell tumor comes under the spectrum of ghost cell lesions.
Calcifying epithelial odontogenic tumor ceot is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. The aim of this study was to integrate the available data published on calcifying odontogenic cyst coc, dentinogenic ghost cell tumor dgct, and ghost cell odontogenic carcinomas gcocs into a comprehensive analysis of their clinicoradiological features, treatment, and recurrence. The tumor appears on the torn or cut end of the nerve, where it forms a ball or swelling varying in size, on the proximal termination of the nerve fiber radiographically. Dentinogenic ghost cell tumor dgct is a rare tumor that often shows an aggressive growth pattern. Dentinogenic ghost cell tumors dgct are very rare tumors. Central dgct may have a locally invasive behavior with variable rates of recurrence. Dentinogenic ghost cell tumour ghost cell odontogenic carcinoma table 1 subtypes of ameloblastoma. Histologically, it consists of ameloblastomalike odontogenic epithelial proliferations.
Credit for the earliest clinical presentation of odontoma associated calcifying cystic odontogenic tumor belongs to the american radiology. The early history of odontogenic ghost cell lesions. Dentinogenic ghost cell tumor dgct is an uncommon locally invasive neoplasm, representing approximately 1. This is an open access article distributed under the terms of the creative commons attributionnoncommercialsharealike 3. Dentinogenic ghost cell tumor a neoplastic variety of calcifying odontogenic cyst. This definition appears very rarely and is found in the following acronym finder categories. Tumor growth and progression were examined by in vivo mri and histopathology at 7, 14, 21, and 28 days following cell injection. Peripheral dentinogenic ghost cell tumor kamat ss, diwakar. Aggressive epithelial odontogenic ghost cell tumor in the. Odontogenic tumor definition of odontogenic tumor by. The 2016 world health organization classification of tumors of the central nervous system. A ghost cell is an enlarged eosinophilic epithelial cell with eosinophilic cytoplasm but without a nucleus.
Eogct stands for epithelial odontogenic ghost cell tumor. It describes the epidemiologic, radiologic, and histopathologic features of presently known neoplasms and hamartomatous or tumorlike lesions arising from the toothforming structures, as well as a number of distinctive jaw lesions that must be distinguished from odontogenic. Described initially as a neoplastic variant of calcifying odontogenic cyst coc, dentinogenic ghost cell tumor dgct was categorized as a separate. One year later, at the time of reporting the case, unfortunately, the patient passed away and he. Notch signaling and ghost cell fate in the calcifying. Wnt signaling as a possible promoting factor of cell. Copy of dentinogenic ghost cell tumor ready dental. Odontogenic tumours are rare lesions and many nonspecialist histopathologists will not have seen many during their working lifetime. The dentinogenic ghost cell tumor dgct is a rare benign odontogenic tumor histologically characterized by islands of odontogenic epithelium with the presence of ghost cells and dysplastic dentin at different stages of calcification. This is a retrospective study of patients with dgct who underwent one or multiple surgical interventions during the 10year period from 1997 to 2007. Odontogenic keratocysts make up around 19% of jaw cysts.
Notch signaling is an evolutionarily conserved mechanism that enables adjacent cells to adopt different fates. Dentinogenic ghost cell tumors dgct are uncommon neoplasms classified as solid variants of calcifying odontogenic cyst and are defined as a locally invasive neoplasm, characterized by ameloblastomalike islands of aberrant keratinization of odontogenic epithelium in the form of ghost cells in association with dysplastic dentin. We present a new case of pdgct located in the maxillary premolar gingiva of a. Aberrant keratinization may be found in the form of ghost cells in association with varying amounts of dysplastic dentin. At the time of writing 2016, it is still the most widely used classification system although a new revision is due to come up in 2017. New findings and controversies in odontogenic tumors. Calcifying odontogenic cyst, dentinogenic ghost cell tumor, gorlins. Although gcs are present in a variety of odontogenic lesions notably the calcifying cystic odontogenic tumor. These authors preferred the term epithelial odontogenic ghost cell tumor to dentinogenic ghost cell tumor, because the latter connotes a mesenchymal tissue origin and the production of true dentin, whereas. Pdgct occurs in older adults most commonly in the anterior mandibular region. New findings in odontogenic tumors e557 1% of all ot in most of the published series worldwide. Coc constitute 12% of all odontogenic tumors and 214% of coc are mainly solid tumors 1.
Dgct has a high recurrence rate after tumor resection. It is a locally invasive neoplasm that is characterized by ameloblastomalike epithelial islands, ghost cells and dentinoid. Dentinogenic ghost cell tumor a neoplastic variety of. Our cytoselect clonogenic tumor cell isolation kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from. The epithelial odontogenic ghost cell tumor eogct is an uncommon odontogenic lesion that is closely linked histologically to the calcifying odontogenic cyst coc. Uniqueness and rarity of the lesion is evident from the literature. This case report describes the thirteenth known case of ceot with maxillary sinus extension and the second one that also involves the buccal vestibule mucosa with peculiar histopathological and. A case of dgct in a 40yearold female patient is being reported. Most of them show only faint traces of nuclear material. Most investigators today accept that eogct is a neoplastic, solid tumor counterpart of coc. They are locally invasive neoplasms and their main characteristic features are ameloblastoma like odontogenic epithelial proliferation, an aberrant keratinization in the form of ghost cells and dysplastic dentin. Dentinogenic ghost cell tumor dgct is an uncommon locally invasive odontogenic tumor regarded by many as a variant of calcifying odontogenic cyst. Dentinogenic medical definition merriamwebster medical.
Please tell us where you read or heard it including the quote, if possible. It most often affects the posterior mandible and most commonly presents in the third decade of life. This tumor appears to be more common in asians based on the cases that have been reported and is more common in the maxilla than the mandible. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. It shows slight male predilection with a tendency to occur in the anterior segment of the jaws canine to first molar, with equal frequency in maxilla and mandible. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst.
This tumor within bone produces a radiolucent defect of varied shape, but it has welldefined borders non specific appearance. Dentinogenic ghost cell tumor dgct is an uncommon locally invasive odontogenic neoplasm. Dentinogenic ghost cell tumor dgct, also known as odontogenic ghost cell tumor, is considered as a rare neoplastic variant of calcifying odontogenic cyst coc. In some cases these small calcifications combine to form large.
In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic. Standardization of an orthotopic mouse brain tumor model. This report presents a case of peripheral dgct on the left side of the mandibular alveolar ridge of a heavy smoker, a 68yearold man, with main presenting feature as a mild pain. The peripheral variant of this clinical rarity appears as a wellcircumscribed mass mimicking a nonspecific gingival enlargement. According to who 2005, ghost cell odontogenic carcinoma is a malignant epithelial tumor with features of calcifying cystic odontogenic tumor or dentinogenic ghost cell tumor classified as an odontogenic carcinoma, which includes. Dentinogenic ghost cell tumor first proposed by praetorius in 1981 synonyms. Dentinogenic ghost cell tumors dgct are uncommon lesions mainly with rare peripheral types. The most notable features of this pathologic entity are histopathological features which include a cystic lining demonstrating characteristic. In 1962, coc was recognized as a distinct clinicopathological entity by gorlin et al. The diagnosis and treatment of dentinogenic ghost cell tumor.
Dentinogenic ghost cell tumors dgct are very rare tumors considered as solid variants of calcifying epithelial odontogenic cysts ceoc. Microscopic appearance of odontogenic epithelium admixed with focal areas of. Among them, the peripheral dentinogenic ghost cell tumor pdgct is an extremely rare benign odontogenic neoplasm with up to 30 cases published in the literature. Combining the radiographic image and the cytology the mass was. The 2005 who histological classification of odontogenic tumors lays out a classification system for neoplasms and other tumors related to the odontogenic apparatus. Maxillary calcifying epithelial odontogenic tumor with. The 2016 world health organization classification of. Dentinogenic ghost cell tumor dgct was described by praetorius et al. Dentinogenic ghost cell tumora rare case report with.
Pdf a 67 year old man with a gingival mass of six months duration was evaluated by aspiration cytology and excisional biopsy. This book greatly expands the body of knowledge in the field of odontogenic tumor pathology. The extraosseous odontogenic tumors may raise diagnostic challenges due to their imitation for reactive gingival lesions. The calcifying ghost cell odontogenic cyst cgcoc was first described by gorlin et al.
Dentinogenic ghost cell tumor dgct is a rare tumorous form of calcifying odontogenic cyst and only a small number of cases have been described. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. The purpose of this study is to assess the diagnosis, treatment and prognosis of the dentinogenic ghost cell tumor dgct. Dentinogenic ghost cell tumor journal of oral disease marker.
191 828 975 606 1075 939 737 41 1015 1115 137 209 177 940 287 15 1198 1106 386 1232 1485 417 299 1129 1266 616 786 1159 1012 643 102 1198 166 488 495 567 1538 61 417 1380 1150 1187 968 1389 654